Using a murine model, Arvind Bhimaraj, MD, MPH Associate Professor of Clinical Cardiology and Interim Chief, Division of Heart Failure, Houston Methodist DeBakey Cardiology Associates demonstrated phenotypic and genotypic reversal from the heart failure state. His team also obtained heart tissue from patients when their cardiac assist devices were implanted and again when they received a heart transplant to compare the tissue compositions. This investigation validated the murine model since the results correlated with human heart failure specimen data. It also emphasized the significance of cell fate transitions between endothelial and mesenchymal cell types in the pathophysiology (convergence of pathology and physiology) of heart failure. Bhimaraj is expanding these findings with NIH-funded studies designed to better understand the role of both myocytes and non-myocytes in natural recovery and develop future potential therapeutic targets.