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Cycle of Translation
From Discovery to Clinic
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Cycle of Translation
Cycle of Translation
A Transformational Vision for Medical Research
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Houston Methodist met the challenge of translation early in the design of the Research Institute building. It houses the essential services and technology that support the full cycle of development to efficiently and effectively deliver innovations to the clinic.
Translating laboratory innovations into treatments for patients is fraught with challenges. The lack of specialized translational research resources makes it extremely difficult and expensive for most institutions to turn fundamental discoveries into tangible solutions that benefit the public. Their most promising innovations perish in the "Valley of Death" before they reach the clinic. We provide support at every step of the cycle of translation, from bridge funding to technical expertise with U.S. Food and Drug Administration (FDA)-approved current good manufacturing practice (cGMP) facilities, good laboratory practice (GLP) facilities and clinical trial operations. The most promising innovations have a lifeline at Houston Methodist.
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Invention Inventions that solve a problem have real world value and protectable intellectual property.
Education & Implementation Interprofessional education programs employ the latest advances in simulation and implementation science to facilitate the safe and efficient adoption of new technologies as they are approved for clinical use.
Quality & Safety As part of the systemwide goals for quality improvement and patient safety, we develop our education programs to incorporate high reliability organization principles and use team-based training approaches to maximize patient outcomes.
Patient Care & Outcomes The Cycle begins and ends with the care of patients in our hospitals and clinics. Clinicians in our hospitals care for more than 2.2 million patients annually, enabling them to identify the most pressing challenges in medicine and provide excellent care.
Clinical Needs Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
Product Development Product development involves the design and piloting of a test product or process within a cGMP or other controlled environment.
Exploratory Research Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process.
Clinical Trials Teams have access to early phase trial support, pharmacokinetics and pharmacodynamics support and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials.
Preclinical Validation Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
Applied Research
Applied research involves testing, evaluating and refining new materials, devices and systems or methods into a final lead experimental product or process with the intent to move into the product development stage.
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Product Development
Product development involves the design and piloting of a test product or process within a cGMP or other controlled environment.
Preclinical_Validation.svg
Preclinical Validation
Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
Clinical_Trials.svg
Clinical Trials & Studies
Teams have access to early phase trial support, pharmacokinetics and pharmacodynamics support and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials.
Education_and_Adoption.svg
Education & Implementation
Interprofessional education programs employ the latest advances in simulation and implementation science to facilitate the safe and efficient adoption of new technologies as they are approved for clinical use.
Outcomes_and_Quality.svg
Quality & Safety
As part of the systemwide goals for quality improvement and patient safety, we develop our education programs to incorporate high reliability organization principles and use team-based training approaches to maximize patient outcomes.
Patient_Care.svg
Patient Care & Outcomes
The Cycle begins and ends with the care of patients in our hospitals and clinics. Clinicians in our hospitals care for more than 2.2 million patients annually, enabling them to identify the most pressing challenges in medicine and provide excellent care.
Clinical_needs.svg
Clinical Needs
Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
Exploratory_Research.svg
Exploratory Research
Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process.
Invention.svg
Invention
Inventions that solve a problem have real world value and protectable intellectual property.
Applied_Research.svg
Applied Research
Applied research involves testing, evaluating and refining new materials, devices and systems or methods into a final lead experimental product or process with the intent to move into the product development stage.
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