METHODOLOGY
Research & Education Stories From Houston Methodist
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Clinical Research
An Answer to a Transplant Problem
In an effort to maximize living donor kidney utilization, Houston Methodist researchers describe the use of deceased donor vein extension grafts for right-sided living donor kidneys and report single-center experience using this technique.
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Guardians of the Galacardins
As an Infectious Diseases Society of America Center of Excellence, The Houston Methodist Antimicrobial Stewardship Program embodies our mission to solve the toughest problems confronting patients.
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Could Cardioneuroablation Replace Permanent Pacemakers?
Houston Methodist Researchers Demonstrate the First Case Study in Which Cardioneuroablation Successfully Abolished Heart Block in a Patient with a Triple Orthotopic Heart Transplant.
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From the Humble Fly, Great Discoveries are Made
Hyunglok Chung, PhD, has found the
Drosophila
fruit fly a key partner in discovering ultra-rare and previously unknown diseases, as well as developing new treatments for already known maladies.
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Cell Division Aberrations Caused by Cigarette Smoke Could Help Detect Cancer Early
Houston Methodist researchers have found that exposure to cigarette smoke can induce both centrosome amplification and clustering in normal lung epithelial cells, making them cancerlike.
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Complementing Treatments for Myasthenia Gravis
Complement protein 5 inhibitors have emerged as a new line of treatment for the debilitating neuromuscular disorder. Now, a clinical study at Houston Methodist is testing the drugs’ long-term efficacy and safety.
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New FDA-Approved Drug Could Be the Much-Awaited Panacea for Alzheimer’s
A phase III clinical study is testing lecanemab in slowing the onset of cognitive decline.
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An Ongoing Phase II Clinical Trial for Bladder Cancer
Combining Neoadjuvant Drug Sasanlimab and Stereotactic Body Radiotherapy May Improve The Quality Of Life In Muscle-Invasive Bladder Cancer Patients
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Antimicrobial Resistance Research is DYNAMITE at Houston Methodist
Houston Researcher leads multi-institutional NIH P01 to tackle antimicrobial resistance termed DYNAMITE: Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients
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Do Motor Neurons First Die in the Brain? Study Provides Clues about ALS Origins
Transcranial rotating permanent magnet stimulation on ALS patients provides insights into the pathogenesis of the debilitating motor neuron disease.
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Houston Methodist joins the Gulf Coast Consortia
Consortia is comprised of eight hospitals, medical schools and research entities in the Texas Medical Center
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A New FDA-Approved Treatment for Sufferers of Chronic Constipation
A capsule designed to vibrate in the GI tract to stimulate the bowels accelerates movement in the field of chronic constipation.
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Houston Methodist Conducts First-Ever Study into a Challenging Condition
Functional Defecatory Disorder study finds key differences in activation patterns of patients' brains
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Can regulating cellular aging mitigate both cancer and heart disease?
Can regulating cellular aging mitigate both cancer and heart disease?
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Improved options for patients with severe retinal vascular disease
In Phase III clinical trials, faricimab met noninferiority endpoints against current drug, aflibercept, to treat diabetic macular edema and neovascular age-related macular degeneration.
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Innovative Treatment for Chronic Rhinitis is Safe and Effective
Takashima and his team conducted a multi-institutional trial to determine the safety and efficacy of temperature-controlled radiofrequency (RF) neurolysis of the posterior nasal nerve area for the treatment of chronic rhinitis.
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Rare wrist bone fusion sighting in collegiate baseball pitcher
In a serendipitous finding, Houston Methodist orthopedic surgeons discover a rare bilateral carpal fusion in the wrist of a high-level collegiate athlete.
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Masters of disguise: Glioblastomas trick the immune system by masquerading as reproductive tissue
By conducting an in-depth analysis of four glioblastoma transcriptome databases Houston Methodist researchers have found that glioblastoma expresses a variety of male- and placental-specific proteins to lure regulatory T cells into protecting rather than attacking it.
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Novel drug combination can target triple-negative breast cancer for treatment
In a Phase I/II clinical trial, Houston Methodist researchers paired a conventional chemotherapy drug with a pan-nitric oxide synthase inhibitor to successfully target triple-negative breast cancers.
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Houston Methodist researchers review the similarities and contrasts of amphibian regeneration and mammalian cancer from an evolutionary biology perspective
Investigators speculated that susceptibility to cancer development in adult mammals may be determined by the loss of an advanced regenerative capability during evolution.
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Houston Methodist and Purdue University Make a Breakthrough That May Result in a More Effective Tuberculosis Vaccine
A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice
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Houston Methodist researchers identify over 50 long-term effects of COVID-19
Lingering symptoms range from mild to debilitating and last for weeks to months after recovery
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The COVID-19 virus SARS-COV-2 affects the brain and may cause long-range complications
Mounting evidence suggests that the SARS-COV-2 virus responsible for COVID-19 causes neurological complications in addition to the signature respiratory symptoms.
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George and Angelina Kostas Gifts Help Houston Methodist Become Leaders in Heart and Vascular Nanotechnology Research
A generous gift from the Kostases allowed the Houston Methodist Academic Institute to begin operations at the George and Angelina Kostas Research Center for Cardiovascular Nanomedicine in 2014.
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Cancer cell type (seed) and tumor microenvironment (soil) control therapeutic antibody delivery and efficacy
Primary tumor cells (seed) and metastatic organs (soil) determine complex tumor microenvironment heterogeneities- a major cause of resistance against immunotherapeutics, including immune checkpoint inhibitors important in breast cancer treatment strategies.
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Semantic dementia study yields new findings
Inflammation research uncovers likely therapeutic target for neurodegenerative aphasia disorder
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Poly ADP Ribose Polymerase 9 (PARP9):
A novel role of Poly ADP Ribose Polymerase 9 (PARP9) as a non-canonical RNA sensor suggests a potential for therapeutic interventions to control RNA virus infections.
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Acetyl-CoA Synthetase 2 connects obesity and myeloma pathogenesis
Comprehensive detailed analyses using mouse models and cell lines identify acetyl CoA synthetase 2 as a pivotal player controlling the dynamic communication between adipocytes and myeloma cells during myeloma pathogenesis.
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New Findings Offer Improved Therapy for Early-Stage, BRCA Mutation-Associated Breast Cancer
New treatment demonstrates it has the potential to improve the outcomes for patients with hereditary BRCA mutations
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The Heart of Progress
Innovative valves continue DeBakey legacy for the future
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Antibody to Fight Silent Killers
Joining forces to block MFAP5 protein in killer cancers
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Revolutionizing Stroke Recovery
TRPMS cap reveals—and recovers—brain function
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Strides in Dialysis Access
Eric Peden, MD, performs first minimally invasive surgery
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Plasma Therapy Proves Transformative
First to offer clinical trial and publish a study, Houston Methodist sees happy outcome for COVID-19 patient
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Antiviral May Offer New Treatment Option
New antiviral drug tested for COVID-19 patients
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Trials Aim to Calm Cytokine Storms
Intensivist focuses on fighting dysregulated immune response
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Safe Refuse for N95s
System Quality & Patient Safety teams develop autoclaving protocol
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Remdesivir Proves Promising
Antiviral drug trial sees fast improvement for Houston Methodist patients
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