President’s Letter
2021 Metrics
Cycle of Translation
Visionary Gifts
Discovery to Clinic
Innovative Education
Translational Luminaries
Introduction
Jerold B. Katz Academy of Translational Research
Infectious Diseases Research Fund
Houston Methodist Dr. Mary and Ron Neal Cancer Center
Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist
The Food & Health Alliance within the Houston Methodist Lynda K. and David M. Underwood Center for Digestive Disorders, Immunology Center and the Fondren Inflammation Collaborative
Houston Methodist Cockrell Center for Advanced Therapeutics
Paula and Joseph C. “Rusty” Walter III
Translational Research Initiative
COVID-19 Studies
Outcomes Research
Restorative Medicine
Houston Methodist Advances Research into Neural Prosthetics
Noninvasive Spinal Stimulation Works to Restore Movement After Spinal Cord Injury
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
Cell Encapsulation May Hold the Key to Preventing Cell Transplant Rejection
Houston Methodist, Rice University, Baylor College of Medicine Design Noninvasive Tech to Help Remove Brain’s Metabolic Waste
Houston Methodist Investigators Nanotechnology Investigators Awarded Prestigious Grants from the Department of Defense
Precision Medicine
Cancer Cell Type (Seed) and Tumor Microenvironment (Soil) Control Therapeutic Antibody Delivery and Efficacy
Novel Drug Combination Can Target Triple-Negative Breast Cancer for Treatment
A Houston Methodist and Purdue University Breakthrough May Result in a More Effective Tuberculosis Vaccine
Importance of the Coronary Artery Calcium Score in Risk Assessment and Prevention of Atherosclerotic Cardiovascular Disease
New Virtual Intensive Care Unit Simultaneously Improves Patient Care and Bed Capacity
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Introduction
Joint Weill Cornell–Houston Methodist Academic Institute Doctoral Program Welcomes its Inaugural Class
Visionary EnMed Program Soars to New Heights
Neural Control of Organ Degeneration and Regeneration (NeuralCODR) Training Program
Faculty and Research Development
Graduate Medical Education
Science in Service
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Medicineresult
President's letter
2021 Metrics
Cycle of Translation
Visionary Gifts of Hope
Introduction
Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist
Houston Methodist Dr. Mary and Ron Neal Cancer Center
The Food & Health Alliance within the Houston Methodist Lynda K. and David M. Underwood Center for Digestive Disorders, Immunology Center and the Fondren Inflammation Collaborative
Houston Methodist Cockrell Center for Advanced Therapeutics
Paula and Joseph C. “Rusty” Walter III Translational Research Initiative
Jerold B. Katz Academy of Translational Research
Infectious Diseases Research Fund
From Discovery to Clinic
What is "Discovery to Clinic"?
Restorative Medicine
Houston Methodist Advances Research into Neural Prosthetics
Noninvasive Spinal Stimulation Works to Restore Movement After Spinal Cord Injury
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
Cell Encapsulation May Hold the Key to Preventing Cell Transplant Rejection
Houston Methodist, Rice University, Baylor College of Medicine Design Noninvasive Tech to Help Remove Brain’s Metabolic Waste
Houston Methodist Investigators Nanotechnology Investigators Awarded Prestigious Grants from the Department of Defense
Precision Medicine
Cancer Cell Type (Seed) and Tumor Microenvironment (Soil) Control Therapeutic Antibody Delivery and Efficacy
New Virtual Intensive Care Unit Simultaneously Improves Patient Care and Bed Capacity
Novel Drug Combination Can Target Triple-Negative Breast Cancer for Treatment
A Houston Methodist and Purdue University Breakthrough May Result in a More Effective Tuberculosis Vaccine
Importance of the Coronary Artery Calcium Score in Risk Assessment and Prevention of Atherosclerotic Cardiovascular Disease
Translational Luminaries
From the President
Science in Service of Medicine
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Houston Methodist has served as a pillar of the Houston community since it began in 1919 as a small hospital providing medical care during the Spanish Influenza pandemic. When the COVID-19 pandemic arrived 101 years later, it provided many opportunities to appreciate the foresight of our founders and the resilience, compassion and expertise of our healthcare providers and staff.
Our academic teams worked resolutely throughout the pandemic, contributing to the systemwide COVID-19 response with rapid outcomes studies and clinical trials as well as continuing to make landmark discoveries in each of our Centers of Excellence. This annual report shares some of the stories that embody our mission to meet the most demanding challenges faced by patients and their physicians.
In 2021, our academic community further cemented its position at the center of a global collaborative network that moves medical research from concept to clinical impact and educates healthcare professionals in the latest medical breakthroughs. This year, the Ann Kimball and John W. Johnson Center for Cellular Therapeutics’ dedicated laboratory space was completed. This cGMP facility provides our experts with the in-house capability to develop, manufacture and bring new cell-based treatments to clinical application. The new center is located in Houston Methodist’s Outpatient Center, which is right in the heart of our clinical operations. Our new Center for Translational Neural Prosthetics and Interfaces in partnership with Rice University is bringing together scientists, clinicians, engineers and surgeons to solve clinical problems with neurostimulation and robotics. One exciting new project in this center involves the development of a “sleeping cap” that can analyze and stimulate the proper flow of cerebrospinal fluid to “cleanse” the brain and thus amplify the restorative function of sleep. The U.S. Army has awarded the research group $2.8 million, the first installment of a multiyear grant through the Medical Technology Enterprise Consortium. In 2021, we also welcomed the inaugural class of the Weill Cornell Graduate School doctoral program in Physiology, Biophysics & Systems Biology at Houston Methodist that builds upon our long-standing academic affiliation with Weill Cornell.
None of this work would be possible without the dedication and support of our visionary Houston Methodist Academic Institute board members, generous donors and brilliant faculty. Our work together has established Houston Methodist as a leading academic medical center, and I am honored to be a part of this journey to the future of medicine.
H. Dirk Sostman, MD, FACR
Ernest Cockrell, Jr. Presidential Distinguished Chair, Houston Methodist
Emeritus Professor of Radiology, Weill Cornell Medicine
Distinguished Member, Houston Methodist Research Institute
President, Houston Methodist Academic Institute
Executive Vice President and Chief Academic Officer, Houston Methodist
Houston Methodist Academic Institute Board Members
Judge Ewing Werlein, Jr., Sr. Chair
John F. Bookout, III, Chair
Edward R. Allen, III
David C. Baggett, Jr.
Marc L. Boom, MD
Joseph R. “Rod” Canion
David T. Chao
Stephen I. Chazen
Augustine M.K. Choi, MD
Ernest D. Cockrell, II
Martin S. Craighead
Martha S. DeBusk
W. Leslie Doggett
Antonio M. Gotto, Jr., MD, DPhil
Edward A. Jones
Evan H. Katz
Edwin H. Knight
Kevin J. Lilly
Steven S. Looke
Ransom C. Lummis
David A. Modesett
W. Benjamin Moreland
Gregory V. Nelson
Joe Bob Perkins
Mary Eliza Shaper
Suzanne H. Smith
H. Dirk Sostman, MD
Douglas E. Swanson, Jr.
David M. Underwood, Jr.
Amy Waer, MD
Joseph C. “Rusty” Walter, III
Martha S. Walton
Vision for the Second Century
The Houston Methodist Vision for the Second Century advances the initiatives of utmost importance to the hospital while placing our patients at the center of everything we do. It illustrates the emphasis placed on our academic medicine mission, which includes restorative medicine, precision medicine, outcomes research, clinical research, and innovative education. These elements are supported by the fundamental values and initiatives of Houston Methodist, which define our commitment to advance the practice of medicine and offer our patients leading care.