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Science in Service
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President's letter
2021 Metrics
Cycle of Translation
From Discovery to Clinic
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Cycle of Translation
Cycle of Translation
A Transformational Vision for Medical Research
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Houston Methodist met the challenge of translation early in the design of the Research Institute building. It houses the essential services and technology that support the full cycle of development to efficiently and effectively deliver innovations to the clinic.
Translating laboratory innovations into treatments for patients is fraught with challenges. The lack of specialized translational research resources makes it extremely difficult and expensive for most institutions to turn fundamental discoveries into tangible solutions that benefit the public. Their most promising innovations perish in the "Valley of Death" before they reach the clinic. We provide support at every step of the cycle of translation, from bridge funding to technical expertise with U.S. Food and Drug Administration (FDA)- approved current good manufacturing practice (cGMP) facilities, good laboratory practice (GLP) facilities and clinical trial operations. The most promising innovations have a lifeline at Houston Methodist.
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Clinical Trials Teams have access to early phase trial support (pharmacokinetics and pharmacodynamics), and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials. This is the end phase of the cycle of a cure, opening the door to the future.
Clinical Needs Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
Discovery Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process. Interdisciplinary teams turn ideas into real solutions with sound testing and iterative design.
Preclinical Validation Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
Current Good Manufacturing Practice (cGMP) Manufacturing Houston Methodist is equipped with FDA cGMP-compliant facilities that produce research and clinical-grade therapeutic materials and custom radiopharmaceuticals for preclinical and first-in-human studies.
Patient Care The cycle begins and ends with the care of patients in our hospitals and clinics. Clinicians in our hospitals care for more than 800,000 patients annually, enabling them to identify the most pressing challenges in medicine and provide excellent care.
Good Laboratory Practice (GLP) Preclinical Validation The GLP facilities at Houston Methodist perform risk, safety and efficacy assessment studies in compliance with current FDA guidelines in preclinical models. Adherence to GLP standards is required for safety studies in order to move to clinical trials.
Quality & Outcomes A key component of leading medicine is our culture of quality, safety and innovation. As part of the systemwide goals for quality improvement and patient safety, we develop our education programs to incorporate high reliability organization principles and use team-based training approaches to maximize patient outcomes.
Education & Adoption Throughout our system, we’re building interprofessional education programs that employ the latest strategies, including simulation, to facilitate the safe and efficient adoption of new technologies as they’re approved for clinical use. Bringing a new innovation from the completion of clinical trials to clinic adoption is very time and resource intensive, needing 10 years and $1 billion, on average.
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Patient Care
The cycle begins and ends with the care of patients in our hospitals and clinics. Clinicians in our hospitals care for more than 800,000 patients annually, enabling them to identify the most pressing challenges in medicine and provide excellent care.
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Quality & Outcomes
A key component of leading medicine is our culture of quality, safety and innovation. As part of the system-wide goals for quality improvement and patient safety, we develop our education programs to incorporate high reliability organization principles and use team-based training approaches to maximize patient outcomes.
Clinical_needs.svg
Clinical Needs
Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
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Lab Discovery
Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process. Interdisciplinary teams turn ideas into real solutions with sound testing and iterative design.
Preclinical_Studies.svg
Preclinical Validation
Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
Manufacturing.svg
Current Good Manufacturing Practice (cGMP) Manufacturing
Houston Methodist is equipped with FDA cGMP-compliant facilities that produce research and clinical-grade therapeutic materials and custom radiopharmaceuticals for preclinical and first-in-human studies.
GLP_-Preclinical_.svg
Good Laboratory Practice (GLP) Preclinical Validation
The GLP facilities at Houston Methodist perform risk, safety and efficacy assessment studies in compliance with current FDA guidelines in preclinical models. Adherence to GLP standards is required for safety studies in order to move to clinical trials.
Clinical_trials.svg
Clinical Trials
Teams have access to early phase trial support (pharmacokinetics and pharmacodynamics), and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials. This is the end phase of the cycle of a cure, opening the door to the future.
Education_and_Adoption.svg
Education & Adoption
Throughout our system, we’re building interprofessional education programs that employ the latest strategies, including simulation, to facilitate the safe and efficient adoption of new technologies as they’re approved for clinical use. Bringing a new innovation from the completion of clinical trials to clinic adoption is very time and resource intensive, needing 10 years and $1 billion, on average.
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