President’s Letter
2021 Metrics
Cycle of Translation
Visionary Gifts
Discovery to Clinic
Innovative Education
Translational Luminaries
Introduction
Jerold B. Katz Academy of Translational Research
Infectious Diseases Research Fund
Houston Methodist Dr. Mary and Ron Neal Cancer Center
Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist
The Food & Health Alliance within the Houston Methodist Lynda K. and David M. Underwood Center for Digestive Disorders, Immunology Center and the Fondren Inflammation Collaborative
Houston Methodist Cockrell Center for Advanced Therapeutics
Paula and Joseph C. “Rusty” Walter III
Translational Research Initiative
COVID-19 Studies
Outcomes Research
Restorative Medicine
Houston Methodist Advances Research into Neural Prosthetics
Noninvasive Spinal Stimulation Works to Restore Movement After Spinal Cord Injury
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
Cell Encapsulation May Hold the Key to Preventing Cell Transplant Rejection
Houston Methodist, Rice University, Baylor College of Medicine Design Noninvasive Tech to Help Remove Brain’s Metabolic Waste
Houston Methodist Investigators Nanotechnology Investigators Awarded Prestigious Grants from the Department of Defense
Precision Medicine
Cancer Cell Type (Seed) and Tumor Microenvironment (Soil) Control Therapeutic Antibody Delivery and Efficacy
Novel Drug Combination Can Target Triple-Negative Breast Cancer for Treatment
A Houston Methodist and Purdue University Breakthrough May Result in a More Effective Tuberculosis Vaccine
Importance of the Coronary Artery Calcium Score in Risk Assessment and Prevention of Atherosclerotic Cardiovascular Disease
New Virtual Intensive Care Unit Simultaneously Improves Patient Care and Bed Capacity
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Introduction
Joint Weill Cornell–Houston Methodist Academic Institute Doctoral Program Welcomes its Inaugural Class
Visionary EnMed Program Soars to New Heights
Neural Control of Organ Degeneration and Regeneration (NeuralCODR) Training Program
Faculty and Research Development
Graduate Medical Education
Science in Service
of
Medicineresult
President's letter
2021 Metrics
Cycle of Translation
Visionary Gifts of Hope
Introduction
Ann Kimball and John W. Johnson Center for Cellular Therapeutics at Houston Methodist
Houston Methodist Dr. Mary and Ron Neal Cancer Center
The Food & Health Alliance within the Houston Methodist Lynda K. and David M. Underwood Center for Digestive Disorders, Immunology Center and the Fondren Inflammation Collaborative
Houston Methodist Cockrell Center for Advanced Therapeutics
Paula and Joseph C. “Rusty” Walter III Translational Research Initiative
Jerold B. Katz Academy of Translational Research
Infectious Diseases Research Fund
From Discovery to Clinic
What is "Discovery to Clinic"?
Restorative Medicine
Houston Methodist Advances Research into Neural Prosthetics
Noninvasive Spinal Stimulation Works to Restore Movement After Spinal Cord Injury
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
Cell Encapsulation May Hold the Key to Preventing Cell Transplant Rejection
Houston Methodist, Rice University, Baylor College of Medicine Design Noninvasive Tech to Help Remove Brain’s Metabolic Waste
Houston Methodist Investigators Nanotechnology Investigators Awarded Prestigious Grants from the Department of Defense
Precision Medicine
Cancer Cell Type (Seed) and Tumor Microenvironment (Soil) Control Therapeutic Antibody Delivery and Efficacy
New Virtual Intensive Care Unit Simultaneously Improves Patient Care and Bed Capacity
Novel Drug Combination Can Target Triple-Negative Breast Cancer for Treatment
A Houston Methodist and Purdue University Breakthrough May Result in a More Effective Tuberculosis Vaccine
Importance of the Coronary Artery Calcium Score in Risk Assessment and Prevention of Atherosclerotic Cardiovascular Disease
Translational Luminaries
Discovery to Clinic
Restorative Medicine
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
An Innovative Approach to Treat Even the Most Stubborn-to-Heal Fractures
Our body’s repair machinery is adept at healing many instances of broken bones. Even so, some fractures are just too complex, requiring an innovative therapeutic approach. An invention called 3ZM, developed by Assistant Professor of Orthopedic Surgery Francesca Taraballi, PhD, is designed to help even the most stubborn-to-heal fractures toward a swift path to recovery.
Francesca Taraballi, PhD
Bradley K. Weiner, MD
Unlike other bone grafts that are infused with proteins, such as BMP-2, 3ZM does not contain any protein cargo. Instead, the collagen-based graft is already highly osteogenic. Consequently, 3ZM-based bone recovery is less susceptible to bone growth outside the injury site, which has been an unwanted side effect of current FDA-approved grafts. Furthermore, 3ZM is pliable and can be easily sutured to the location of bone damage, and the material dissolves as the bone heals, leaving no trace other than a healed bone.
In preclinical models, 3ZM guided immune, stem, and bone cells to remodel a fractured area into a functional bone. Within six weeks, the fracture had healed, and the implanted materials were resorbed by the body, leaving the bone strong. As a next step, Taraballi is collaborating with an external agency to conduct toxicology tests so they can apply for FDA approval and bring their innovation a step closer to clinics.
3ZM
Steps in Healing Process
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3 Zonal Membrane (3ZM) is cut and shaped to fit the defect site and then sutured to the surrounding periosteum. The process requires only one operation and no additional growth factors. After four to six weeks, the bone is fully healed, and the 3ZM is absorbed.
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