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Cycle of a Cure
Cycle of a Cure
A Transformational Vision for Medical Research
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Houston Methodist met the challenge of translation early in the design of the research institute building. It houses the essential services and technology that support the full cycle of development to efficiently and effectively deliver innovations to the clinic.
Translating laboratory innovations into treatments for patients is fraught with challenges. The lack of specialized translational research resources makes it extremely difficult and expensive for most institutions to turn fundamental discoveries into tangible solutions that benefit the public. Their most promising innovations perish in the 'Valley of Death" before they reach the clinic. We provide support at every step of the cycle of a cure from bridge funding to technical expertise with U.S. Food and Drug Administration (FDA)-approved current good manufacturing practice (cGMP) facilities, good laboratory practice (GLP) facilities and clinical trial operations. T2 translation allows for the testing of new interventions in a controlled environment and allots time to gain knowledge about the ability of an intervention in an optimal setting. The most promising innovations have a lifeline at Houston Methodist.
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Clinical trials
Teams have access to early phase trial support (pharmacokinetics and pharmacodynamics), and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials. This is the end phase of the cycle of a cure, opening the door to the future.
Clinical Needs
Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
Discovery
Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process. Interdisciplinary teams turn ideas into real solutions with sound testing and iterative design.
Preclinical Validation
Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
Current Good Manufacturing Practice (cGMP) Manufacturing
Houston Methodist is equipped with FDA cGMP-compliant facilities that produce research and clinical-grade therapeutic materials and custom radiopharmaceuticals for preclinical and first-in-human studies.
Good Laboratory Practice (GLP) Preclinical Validation
The GLP facilities at Houston Methodist perform risk, safety and efficacy assessment studies in compliance with current FDA guidelines in preclinical models. Adherence to GLP standards is required for safety studies in order to move to clinical trials.
Patient Care
The cycle begins and ends with patient care. Clinicians in our hospitals care for more than 1.5 million patients annually, enabling them to identify the most pressing challenges in medicine.
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Patient Care
The cycle begins and ends with patient care. Clinicians in our hospitals care for more than 1.5 million patients annually, enabling them to identify the most pressing challenges in medicine.
Clinical_needs.svg
Clinical Needs
Clinicians and researchers form interdisciplinary teams to address their needs and clinical challenges.
Lab_Discovery.svg
Discovery
Our teams of clinicians, researchers, and collaborators from around the world have access to a full suite of technology to enable the discovery process. Interdisciplinary teams turn ideas into real solutions with sound testing and iterative design.
Preclinical_Studies.svg
Preclinical Validation
Research teams have access to dedicated Translational Research Initiative bridge funds to take the most promising discoveries into preclinical and early phase clinical development.
GLP_-Preclinical_.svg
Current Good Manufacturing Practice (cGMP) Manufacturing
Houston Methodist is equipped with FDA cGMP-compliant facilities that produce research and clinical-grade therapeutic materials and custom radiopharmaceuticals for preclinical and first-in-human studies.
Manufacturing.svg
Good Laboratory Practice (GLP) Preclinical Validation
The GLP facilities at Houston Methodist perform risk, safety and efficacy assessment studies in compliance with current FDA guidelines in preclinical models. Adherence to GLP standards is required for safety studies in order to move to clinical trials.
Clinical_trials.svg
Clinical Trials
Teams have access to early phase trial support (pharmacokinetics and pharmacodynamics), and outpatient clinical care and study management services, including research, nursing, regulatory submissions and budget management support for all phases of clinical trials. This is the end phase of the cycle of a cure, opening the door to the future.
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