It is with great pleasure to share our 2025 Annual Report highlighting notable achievements of the Houston Methodist Academic Institute. Philanthropist John F. Bookout, Jr. presented a vision, “Houston Methodist will be for the southern United States what is now found on the two coasts and in the Midwest—a leading academic medical center.” Twenty years later, this vision is realized. The Houston Methodist Academic Institute continues its trajectory of success that followed investing in the visionary ideas of our Centers of Excellence. And they delivered by increasing grant funding from $10M annually to more than $100M annually over 10 years. This success momentum is even stronger. We accepted the challenge at the confluence of uncertainty and probability in science, which is part of our dedicated mission through a global collaborative network that transitions proof-of-concept medical research into clinical impact and educates health care professionals on the latest medical breakthroughs in the service of health. We know Houston Methodist excels in clinical quality and safety outcomes today, but we exist in a constantly changing landscape that requires innovation with science-based programs, such as Sepsis Early Recognition and Response Initiative (SERRI), focused on improving the early identification and treatment of sepsis, a life-threatening condition caused by infection, to truly lead. SERRI put Houston Methodist on the map as the academic medical center that developed early sepsis screening tools that interfaced with our electronic health records and training programs that helped 15 health systems save $50 million in medical costs and 2,500 lives. Houston Methodist is home to the first coronary artery bypass graft and the first multi-organ transplant. Its innovative education programs, such as new translational PhD programs in medicinal chemistry with Rice University and the Texas A&M University EnMed physician engineering school, the quality and safety certifications envisioned, and extended reality simulation education technology being developed at the Bookout Center. Our 2040 Vision Impact charts our National Impact Initiatives for Transforming Care Now through Quality & Safety Innovation, Digital Health, Science Implementation and Transforming Future Patient Care with Healthspan Research, Gene Modulation & Bioengineered Therapeutics, Robotics & Imaging. It is an honor to be on this journey for what lies ahead for Houston Methodist’s future of medicine and human health.