Predicting Treatment Outcomes of Cancer Nanomedicine

Overcoming challenges associated with therapeutic and nanoparticle tumor uptake and tissue penetration is critical for establishing effective cancer therapies. In this work, we demonstrate controlled spatial delivery of intratumorally injected gold nanoparticles (zonal delivery) by leveraging different surface chemistries while minimizing variables in administration through injection with a syringe pump set at constant dispense volume and flow rate. For the field of cancer nanomedicine, there are several fundamental and applied research directions that can be considered. From an applied perspective, a mathematical framework that allows for particle distribution predictions based on surface properties could revolutionize the current methods of personalized medicine.